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ajs
Forum Leader
Username: Ajs
Post Number: 632
Registered: 03-2008
| | Posted on Thursday, August 18, 2011 - 08:09 am: | 
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Does anyone else here have these infusions periodically? I just had one yesterday, as I have one pesky DSA that wants to keep popping up. It's what they call a 'very low titer' of like 6, but Duke feels trying to keep DSA's at bay is good thing. That's the 4th infusion I've had in three years, and I also get IVIG once a month.
Double-Lung transplant at Duke on 10/27/08
Pulmonary Fibrosis with traction bronchiectasis
Live each day as if you were living forever, and live each moment as if it were your last.
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vajohn
Member
Username: Jfarel
Post Number: 302
Registered: 02-2008
| | Posted on Thursday, August 18, 2011 - 05:03 pm: |
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Never mentioned donor specific antibodies with me. I will ask about it...they did mention that many cf post tx patients need iv ig (immuno globulin (sp). It seems to help them w/ issues they have with pseudomonas infections. I may need it in the future they said.
30 years old with Cystic Fibrosis
Bilateral Lung Transplant INOVA Fairfax hospital (June 23, 2010)
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ajs
Forum Leader
Username: Ajs
Post Number: 633
Registered: 03-2008
| | Posted on Friday, August 19, 2011 - 11:18 am: |
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John- You should definitely ask about your HLA panels and see if you have any DSAs. Much science proving they are not good. The HLA panels have to be done with the highly sensitive Luminex method to determine specificity.
Double-Lung transplant at Duke on 10/27/08
Pulmonary Fibrosis with traction bronchiectasis
Live each day as if you were living forever, and live each moment as if it were your last.
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Organ4life
Member
Username: Organ4life
Post Number: 16
Registered: 06-2011
| | Posted on Wednesday, August 24, 2011 - 05:32 am: |
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There are more research done regarding DSA and graft survival. Unfortunately, most of the research is done on kidneys because they have more volume. At my transplant center we are giving a lot more IvIg these days for patient with positive DSA. In the long run DSA seems to be causing chronic rejection.
Transplant coordinator
www.organ-transplants.com |
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ajs
Forum Leader
Username: Ajs
Post Number: 635
Registered: 03-2008
| | Posted on Thursday, August 25, 2011 - 07:51 am: |
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Thanks. Do you not do Rituxan infusions at your center, as well as the IVIG? Honestly, since the science is pretty conclusive, I can't believe not one other person chimed in that they are getting RIT. Funny thing is, they did the study of it's effectiveness at Duke, and the study was published the day of my transplant! Because of that, my insurance had no problem paying.
the study:
http://meeting.chestpubs.org/cgi/content/abstract/134/4/s22003
Double-Lung transplant at Duke on 10/27/08
Pulmonary Fibrosis with traction bronchiectasis
Live each day as if you were living forever, and live each moment as if it were your last.
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Organ4life
Member
Username: Organ4life
Post Number: 17
Registered: 06-2011
| | Posted on Friday, August 26, 2011 - 05:56 am: |
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To my knowledge only one patient that I follow has received rituxan in a case of repetitive acute rejection with DSA.
Transplant coordinator
www.organ-transplants.com |
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