Post Number: 16
|Posted on Tuesday, January 17, 2012 - 09:21 pm: ||
So my husbands creatinine went from 1.86 on Friday to 2.39 today. They were ready to send us to the hospital for fluids and possible biopsy. Then they go the prograf result and his level was 16.1. They said it is probably the prograf. Can prograf really cause that much of an increase in your creatinine in such a short period of time? They told him not to take it tonight and to cut it down to 3 mg tomorrow instead of 4 and they will check him again Thursday. Will the creatinine significantly decrease in that short amount of time? Thanks again for all of your support and words of wisdom. Being new to all of this is very frustrating.
Post Number: 721
|Posted on Wednesday, January 18, 2012 - 12:04 am: ||
IMHO, he is being ODed at 4 mg/day. Unless he is a very large man, (body weight is figured into the dose) most patients take an average dose of 2 mg/day. (One morning, one night). This could have a lot to do with the 1.86, which is higher than many transplants have. Prograf is known to be nephrotoxic, so the ODing could not only cause regularly high creatinines, but could hasten rejection, which he may be be dealing with now. You didn't say how long he has been transplanted.
It is my opinion that most transplants receive too much antirejection medication because most doctors are so fearful of rejection. So, they up the dosage a bit--sometimes quite a bit---in order to be sure to give enough. If they do a biopsy, they will be able to see any damage that has come from overdosing him. I would request--STRONGLY IF NECESSARY--that they look for too much Prograf.
The best to him and you, Tara.
|Kidney Transplant - Aug 30, 1986 - Type One Diabetes |
Liver Transplant - May 15, 2007 - Hepatic Carcinoma due to Hepatitis C
Post Number: 541
|Posted on Wednesday, January 18, 2012 - 01:00 pm: ||
I am a heart transplant recipient and I take 2.5mg prograf in AM an 2mg in PM. That's a total of 4.5mg. I am out 3 years (in 10 days!!!!!) and my creatine has been fine. I think everyone metabolizes these meds differently, hence the diffrence in how much people are on. My center checks my levels every few weeks and wants to see me between 7-9 on my prograf level. With what am I on right now I am at 8.6. With that said.....last Oct on a lower dose (2mg both AM and PM) my level was at 12.3 (still my creatine and BUN levels were fine however I was in a slight rejection?????) Go figure! I had never heard of to high a level causing rejection like Richard said. Richard, where can I find that kind of info? They attribute the changes to how I am metabolizing the medication. Not really sure I understand it all but am glad they check my levels so frequently. I know when my levels were really high I felt really AWFUL, nauseous,tired,shaky,weak. I knew something was off. The farther out you get the more you get to know what's normal and what's not. That is when YOU have to be your own advocate and push for them to investigate what's happening.
Hope this helps.
|Holly Mulkerin |
Heart transplant 1/28/09 I have a Happy Heart
Be kind. Remember that everyone you meet is fighting a hard battle. Harry Thompson
Post Number: 5253
|Posted on Wednesday, January 18, 2012 - 03:25 pm: ||
I take 4 mg of prograf per day also. The fact that I do not take cellcept does have something to do with it, along with the fact that I take 2.5 mg prednisone. I have had no problems at all at this dosage. I believe that Tara's husband just got a transplant recently. In that case, they will be lowering the dosage, most likely.
Post Number: 17
|Posted on Thursday, January 19, 2012 - 10:43 pm: ||
So today his creatinine came back down to 1.89 after they lowered the prograf. He is now on 3 mg per day. He goes back on Tuesday. Hope everything is better then.