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laura
Member
Username: Lovemymom
Post Number: 13
Registered: 06-2011
| | Posted on Wednesday, December 07, 2011 - 04:09 pm: | 
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Ajs, you have mentioned taking NAC. Would you happen to have the link to the study showing the potential benefits? Does anyone else take it daily? Has anyone had any side effects??
Ajs, thank you for all of your extremely valuable information!! |
ajs
Forum Leader
Username: Ajs
Post Number: 679
Registered: 03-2008
| | Posted on Wednesday, December 07, 2011 - 05:04 pm: |
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Hi Laura,
I may be one of the few, although there was someone on the board who was prescribed it when they developed BOS. I know Drs. at Pitt and Stanford are fine with it.
It's simply an amino acid and the only side effects I've read are bothering some people's stomach, which is rare. I've been taking the effervescent form from Europe for eight years or so. The pill form sold here is not pharmaceuticaly made, and is IMO, worthless. I was getting a minimum two cases of bronchitis a year when I started on it, and had one case in the next 3 1/2 years. If you read this study (from Dr. Verleden in Belgium, the first person I saw who did Azithromycin studies), you'll see it has a similar mechanism of action AS the Azithro. The inhibition of the production of IL-8.
Dr. Scott Palmer at Duke told me if he had the money to study five things for the prevention of BOS, NAC would be one of them. Not saying it's a magic bullet, but I believe an essential cog in scavenging free-radicals(reactive oxygen species) and lowering inflammation.
NAC
http://bit.ly/clFwl4
Recently, it has been suggested that reactive oxygen species may also play an important role in the pathogenesis [of BOS] because they are known to induce smooth muscle proliferation.
"We demonstrated that human airway smooth muscle cells, when stimulated with IL-17, are able to produce 8-isoprostane, which could be inhibited by adding N-acetylcysteline, and which was also able to decrease IL-17-induced IL-8 production. The clinical significance of these in vitro findings for prevention or treatment of chronic rejection after lung transplantation remains to be investigated."
Azithromycin
http://bit.ly/96MOYd
Analysis of the BAL fluid confirmed the involvement of IL-17 in patients who developed acute rejection or BOS [4, 5]. A study by Gerhardt et al. [6] has demonstrated, for the first time, a reversal of the disease by macrolides, especially azithromycin; we also focused our attention on the mechanisms of azithromycin. We demonstrated both in vitro and in patients with BOS that innate immunity with IL-8 and neutrophils are key elements to explaining the mechanism of action of azithromycin
and here is another study I found, making quite the case for NAC:
http://bit.ly/ve3M0f
NAC has therapeutic value for reducing endothelial dysfunction, inflammation, fibrosis, invasion, cartilage erosion, acetaminophen detoxification and transplant prolongation. 
Then, you can go even further to see what 'endothelial dysfunction' can cause:
http://bit.ly/rJmKh4
The role of the graft endothelium in transplant rejection: evidence that endothelial activation may serve as a clinical marker for the development of chronic rejection
The graft endothelium may provide an antigen-specific signal to transmigrating, previously activated, T cells and may induce B7 expression on locally transmigrating leukocytes to promote costimulation. Taken together, these functions of the EC provide it with a potent regulatory role in rejection and in the maintenance of T-cell activation via the direct and/or the indirect pathways of allorecognition.
Double-Lung transplant at Duke on 10/27/08
Pulmonary Fibrosis with traction bronchiectasis
Live each day as if you were living forever, and live each moment as if it were your last.
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Jay Lackritz
Forum Leader
Username: Jay_ny
Post Number: 478
Registered: 01-2007
| | Posted on Wednesday, December 07, 2011 - 05:53 pm: |
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When I had COPD, I took NAC daily at the recommended dosage of 600mg twice a day (along with the recommended 2x Vitamin C).
NAC is a common treatment for COPD (and chronic bronchitis) to prevent exacerbations, and break up mucus.
There are always many discussions in the COPD forums on this topic. Here are a few such discussions from only one of the many COPD forums:
https://www.google.com/search?q=site%3A69.72.148.136+nac
When I received my transplant, I tried to reduce the amount of supplements I was taking, and reduce it to just the ones prescribed by my transplant pulmonologist, such as Vitamin D, Folic Acid, Iron, Calcium, etc. With such a huge list of meds I needed to take, I tried to reduce the amount of drugs and supplements to only the ones considered necessary. With the new data on BOS, I might begin to take it again, but NAC should be taken twice a day with a large dosage of C, so this adds many more pills to any regimen.
Study on NAC and respiratory disease:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2706612/
Wiki Page: http://en.wikipedia.org/wiki/Acetylcysteine
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Hostess Rise'
Board Administrator
Username: Rise
Post Number: 16952
Registered: 05-2003
| | Posted on Wednesday, December 07, 2011 - 06:06 pm: |
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Genius!! What can I say about you all.
I am so proud of my buddies and the knowledge they share.
WE are the Empowered ones!
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ajs
Forum Leader
Username: Ajs
Post Number: 680
Registered: 03-2008
| | Posted on Wednesday, December 07, 2011 - 06:19 pm: |
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Jay- I take the 600 mg effervescent tablets twice a day, so I actually dissolve them in water (has a berry flavor), and then use THAT to take my morning and evening pills!
Here is another great article I found listing all the varied benefits of NAC.
http://www.benbest.com/nutrceut/NAC.html
Here is a list of the 225 ongoing studies with NAC at Clinicaltrials.gov. It's mind boggling.
http://clinicaltrials.gov/ct2/results?term=NAC
Double-Lung transplant at Duke on 10/27/08
Pulmonary Fibrosis with traction bronchiectasis
Live each day as if you were living forever, and live each moment as if it were your last.
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ajs
Forum Leader
Username: Ajs
Post Number: 681
Registered: 03-2008
| | Posted on Wednesday, December 07, 2011 - 06:33 pm: |
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I guess since everyone knows that helping people is my main goal here, I must mention my sister's website selling effervescent NAC, the only place in the US to get it. It was a happy result of my initially finding this in Germany, and it helping me avoid bronchitis and possibly staving off the transplant a few years. She has Drs. from all over recommending ALS patients to take NAC, but only effervescent! It makes me very happy that I created a business for her, because as a life-long musician, there weren't no 401K waiting...
http://healthierlungs.com/
Double-Lung transplant at Duke on 10/27/08
Pulmonary Fibrosis with traction bronchiectasis
Live each day as if you were living forever, and live each moment as if it were your last.
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Jay Lackritz
Forum Leader
Username: Jay_ny
Post Number: 479
Registered: 01-2007
| | Posted on Wednesday, December 07, 2011 - 06:35 pm: |
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ajs said "I actually dissolve them in water and then use THAT to take my morning and evening pills! "
Very clever, ajs!
Maybe you should dissolve them in orange juice, rather than water, so you at least get some 'C' with it.
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Hostess Rise'
Board Administrator
Username: Rise
Post Number: 16954
Registered: 05-2003
| | Posted on Wednesday, December 07, 2011 - 06:39 pm: |
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AJS
If I were you I would add your sisters link to your signature.
I am going to read more soon and I will definitely consider taking NAC again. I believe it is good for combating viruses but I will check on this.
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ajs
Forum Leader
Username: Ajs
Post Number: 682
Registered: 03-2008
| | Posted on Wednesday, December 07, 2011 - 06:40 pm: |
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I have not found any supporting articles about the C, Jay, and believe me when I say I've read hundreds. As I said, I get 100 mg in my daily, but I'm afraid of the acid in the stomach that sometimes C can cause. Let me do some more research. And the berry flavor doesn't mix too well with OJ!
Double-Lung transplant at Duke on 10/27/08
Pulmonary Fibrosis with traction bronchiectasis
Live each day as if you were living forever, and live each moment as if it were your last.
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ajs
Forum Leader
Username: Ajs
Post Number: 683
Registered: 03-2008
| | Posted on Wednesday, December 07, 2011 - 06:43 pm: |
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Rise' - That very fact about combating Viruses is in that 'benbest' article up above.
A dose of 1200 mg daily of NAC has significantly reduced (25% versus 79%) influenza-like symptoms in elderly subjects suffering from non-respiratory diseases [EUROPEAN RESPIRATORY JOURNAL; De Flora,S; 10(7):1535-1541 (1997)].}
Double-Lung transplant at Duke on 10/27/08
Pulmonary Fibrosis with traction bronchiectasis
Live each day as if you were living forever, and live each moment as if it were your last.
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Chaneenie
Member
Username: Chaneenie
Post Number: 44
Registered: 01-2008
| | Posted on Wednesday, December 07, 2011 - 07:05 pm: |
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My transplant doctors at St. Joseph's in Phoenix, AZ put me on NAC 600mg 2 x day while I was in the hospital being treated for RSV last March. They sent me home with a script for it, and I was able to buy it at Walgreen's after they special ordered it for me. Two other pharmacists (at Walmart and CVS) didn't know anything about NAC other than it being used for Tylenol overdoses. I now buy it from Amazon. I do take 500-1000mg of Vitamin C everyday, but never heard that NAC should be taken with it.
Double-Lung Transplant at UCSD - Hillcrest: 9.30.1996
Living-Related Kidney Transplant at UCSD - Hillcrest: 11.17.2004
Lung TX for Diagnosis: Bronchiotis Obliterans w/ Organizing Pneumonia / Bronchiectasis
Current FEV1: 92%, Happily married w/ 1 child. =)
Organ Donation Awareness T-Shirts - http://coolteesetc.spreadshirt.com
My Website - http://www.loscarrs.com |
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Starla
Member
Username: Starla_sagehotmailcom
Post Number: 69
Registered: 01-2010
| | Posted on Wednesday, December 07, 2011 - 07:13 pm: |
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FYI
IPF patients take NAC prior to transplant at my center. I asked if they took it after and they said no. I will find out why as it makes sense. But with IPF there really aren't many options. I can hear them tell me as usual, since there isn't enough research they can't recommend it.
Starla
Celebrate Life!
Bilateral Lung Tx 2/12//11
Sarcoidosis 6/04/04
UW Med Center Seattle |
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ajs
Forum Leader
Username: Ajs
Post Number: 684
Registered: 03-2008
| | Posted on Wednesday, December 07, 2011 - 08:23 pm: |
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Starla- Same thing Duke said to me, but around the same time, Dr. Palmer is telling me he wants to study it for prevention of BOS. Stanford and Pitt have no problem with it, according to people I've asked, but do what makes sense for you. I know it's a tough barrier to get across, doing something your way when the docs aren't telling you to.
For the record, Duke said the same thing about Azithromycin, I started taking it anyway, and a month later when I went in with my FEV up 15%, the Dr. says "Well, I have to hand it to you....."
Double-Lung transplant at Duke on 10/27/08
Pulmonary Fibrosis with traction bronchiectasis
http://healthierlungs.com/
Live each day as if you were living forever, and live each moment as if it were your last.
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Jay Lackritz
Forum Leader
Username: Jay_ny
Post Number: 480
Registered: 01-2007
| | Posted on Friday, December 09, 2011 - 09:49 am: |
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ajs,
You said that the pill form is useless. This is what most people use. Are you saying that the form that your wife sells is the only form of NAC that works?
Most people I know just order the pills from Puritan's Pride, or from their local health food store. Are they all just throwing away their money?
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vajohn
Member
Username: Jfarel
Post Number: 317
Registered: 02-2008
| | Posted on Friday, December 09, 2011 - 11:19 am: |
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Jay, I thought I would weigh in. Long before I met ajs, I had tried effervescent nac tablets. I was told the same thing. The capsules in health food stores are nxt to useless. It has to do with oxidation.. The effervescent stuff, is European pharmaceutical grade, and it must meet certain requirements. In other words, it is regulated and has been tested for it's quality and efficasy. The stuff sold in American health food stores is not the same quality. That is what I have heard. This was a large discussion on thr cf boards a few years ago. The good thing is, the effervescent stuff doesn't smell like rotten eggs, as opposed to the health food store brands.
30 years old with Cystic Fibrosis
Bilateral Lung Transplant INOVA Fairfax hospital (June 23, 2010)
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vajohn
Member
Username: Jfarel
Post Number: 318
Registered: 02-2008
| | Posted on Friday, December 09, 2011 - 11:22 am: |
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Stanford tested nac to reduce inflammation in cystic fibrosis. I know they used the effervescent nac tabs.
30 years old with Cystic Fibrosis
Bilateral Lung Transplant INOVA Fairfax hospital (June 23, 2010)
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ajs
Forum Leader
Username: Ajs
Post Number: 688
Registered: 03-2008
| | Posted on Friday, December 09, 2011 - 11:23 am: |
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Jay- Maybe useless was a bit harsh, but most doctors that are recommending their ALS patients to use NAC, tell them to only use effervescent. There was a study done by Leonore Herzenberg at Stanford with the finding that NAC tends to degrade and destabilize in the presence of air, and therefore was of inconsistent quality and dosage. The link I had is broken, but I found a patent application from the same researchers stating the same thing. It's very long, but I've copied the relevant passage:
http://www.faqs.org/patents/app/20110014285
NAC Packaging: Stability
[0082]Over-the-counter NAC can be produced variably and packaged. Because production and packaging methods generally do not guard against oxidation, NAC can be significantly contaminated with bioactive oxidation products. These may be particularly important in view of data indicating that the oxidized form of NAC has effects counter to those reported for NAC and is bioactive at doses roughly 10-100 fold less than NAC (see Samstrand et al (1999) J. Pharmacol. Exp. Ther. 288: 1174-84).
[0083]The distribution of the oxidation states of NAC as a thiol and disulfide depends on the oxidation/reduction potential. The half-cell potential obtained for the NAC thiol/disulfide pair is about +63 mV, indicative of its strong reducing activity among natural compounds (see Noszal et al. (2000) J. Med. Chem. 43:2176-2182).
[0084]It therefore is highly desirable that the APAP-NAC formulation is prepared and stored so that oxidation of the reduced form of NAC is minimized. When in solution. NAC containing formulations may be stored in a brown bottle that is vacuum scaled. In some embodiments, storage is in a cool dark environment. In some embodiments, NAC containing formulations in solid form are blister packed under gas. In some embodiments, APAP:NAC formulations are formulated as a tablet, wherein the tablet comprises antioxidants. In some such embodiments, the tablet is uncoated. In some such embodiments, the tablet is coated with a coating that acts to, for example, limit oxygen transfer or photolability. According to another embodiment, the composition further comprises stabilizing agents. Stabilizing agents may include, but are not limited to, antioxidants. Such agents may act to, for example, but not limited to, inhibit oxygen transfer or photolability.
[0085]The determination of reduced and oxidized species present in a sample may be determined by various methods known in the art, for example, with capillary electrophoresis, HPLC, etc. as described by Chassaing et al. (1999) J Chromatogr B Biomed Sci Appl 735(2):219-27.
In the original article, it concluded that individually wrapped in foil effervescent tablets were the highest quality delivery system. If you've smelled that sulphur smell when opening a bottle of pills, that is the oxidizing effect. When you take them out of the foil, that smell is not there.
Double-Lung transplant at Duke on 10/27/08
Pulmonary Fibrosis with traction bronchiectasis
http://healthierlungs.com
Live each day as if you were living forever, and live each moment as if it were your last.
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vajohn
Member
Username: Jfarel
Post Number: 319
Registered: 02-2008
| | Posted on Friday, December 09, 2011 - 11:29 am: |
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Also, pharmacy grade effervescent nac is widely available. Not just from ajs
Of course, if I was going to try it again, I'd buy it from his sister
30 years old with Cystic Fibrosis
Bilateral Lung Transplant INOVA Fairfax hospital (June 23, 2010)
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ajs
Forum Leader
Username: Ajs
Post Number: 689
Registered: 03-2008
| | Posted on Friday, December 09, 2011 - 11:53 am: |
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From where, John? We only know of a Canadian company that sells it for almost twice the price. And theirs has Aspartame, which my sister is vehemently against. The German brand uses Mannitol as a sweetener.
Double-Lung transplant at Duke on 10/27/08
Pulmonary Fibrosis with traction bronchiectasis
http://healthierlungs.com
Live each day as if you were living forever, and live each moment as if it were your last.
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Jay Lackritz
Forum Leader
Username: Jay_ny
Post Number: 481
Registered: 01-2007
| | Posted on Friday, December 09, 2011 - 02:07 pm: |
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That's kind of what I meant, ajs.
I haven't seen the effervescent form sold anywhere, yet there are a very many people who report that NAC helps their mucus problems after taking it for a couple of weeks. I have heard people swear by how well it works, but they are all taking it in pill form.
Could just be the placebo effect, but if only the effervescent form worked, you'd think that it would turn up on any google search for nac, and that most people would be using it, rather than using pills. Weird that the pills that so many people take have no effect, and that this would not be well known.
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ajs
Forum Leader
Username: Ajs
Post Number: 690
Registered: 03-2008
| | Posted on Friday, December 09, 2011 - 02:18 pm: |
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Not saying it would have no effect. Just from a consistent dosage standpoint, there must be a reason why they make it pharmaceutically in Europe. And supposedly the bioavailability is greater from effervescent.
So maybe all those people would have even better results with effervescent? I don't know, but I do know that in Europe they are not about gouging people for drugs, and I frankly don't think they would bother doing it this way, if the pill was just as good. Each to his own, of course.
Double-Lung transplant at Duke on 10/27/08
Pulmonary Fibrosis with traction bronchiectasis
http://healthierlungs.com
Live each day as if you were living forever, and live each moment as if it were your last.
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vajohn
Member
Username: Jfarel
Post Number: 320
Registered: 02-2008
| | Posted on Saturday, December 10, 2011 - 01:41 am: |
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Just google effervescent nac. I wasn't necessarily saying there were multiple manufacturers, just appeared to be several websites selling it.
30 years old with Cystic Fibrosis
Bilateral Lung Transplant INOVA Fairfax hospital (June 23, 2010)
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vajohn
Member
Username: Jfarel
Post Number: 321
Registered: 02-2008
| | Posted on Saturday, December 10, 2011 - 01:53 am: |
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It's available through: Sears, amazon, iherb.com among others.
I assume we are talking about the same thing: pharmaNAC
30 years old with Cystic Fibrosis
Bilateral Lung Transplant INOVA Fairfax hospital (June 23, 2010)
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ajs
Forum Leader
Username: Ajs
Post Number: 691
Registered: 03-2008
| | Posted on Saturday, December 10, 2011 - 11:17 am: |
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We are, John. I just checked Amazon and they are selling 20 for the same price my sister sells 40. The extra 300 mgs per tablet doesn't really matter, because you'd still need to take 2 a day to get the recommended dosage of 1200. Thanks for that info!
My sister sent me these emails today from a new customer, and it just makes you feel so good. And she's gotten 100 very similar.
I am extraordinarily surprised. I have had 3 glasses of NAC and the difference is amazing. I noticed right after the first glass. Didn't notice much after the second one because I just went to bed. But this morning, the third glass, the heaviness in my lungs feels a whole lot less.
I have had post-nasal drip all my life and whole history of problems resulting from mucous and respiratory problems since birth - for 59 years. Suddenly I could not breathe or stop coughing. I have just been diagnosed with COPD. It's not gone yet, but the change is incredibly noticeable. You can count me as a long-term client and I can hardly wait until further drinks of NAC to see what happens.
Thank you so much
Jessica
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I would like to add to my last email that for the first time in 6 months, the heaviness in my lungs is almost gone. Seriously, it is so lessened that I completely forgot I had a heaviness until I just remembered now.
This stuff is amazing!
Jessica
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Another addition to my 2 former emails.
I have barely been able to talk - some days not even being able to open my mouth without coughing uncontrollably.
Today, this afternoon, for the first time in several months, I could actually sing.
It is not gone yet. But an incredible improvement after just 3 doses. Tonight, I do another one. Good find!
Thank you again
Jessica
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Thank you so much for everything. A little more update - I had my 4th dose last night and added C, Zinc and Selenium for the first time. I wake up every morning just struggling for air - it is so heavy and my lungs are so heavy.
This morning, I woke up like my old self - no heavy lungs at all. My breathing is normal and wonderful. I am in a state of shock.
Thank you for final relief after months of agony. And I will certainly do the cold thing. I have had pneumonia/bronchitis every year of my life and last time seemed to push me over the hump into COPD.
I don't even have mucous this morning. No coughing at all.
This is wonderful.
God bless you
Jessica
Double-Lung transplant at Duke on 10/27/08
Pulmonary Fibrosis with traction bronchiectasis
http://healthierlungs.com
Live each day as if you were living forever, and live each moment as if it were your last.
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Hostess Rise'
Board Administrator
Username: Rise
Post Number: 16966
Registered: 05-2003
| | Posted on Tuesday, December 13, 2011 - 07:03 pm: |
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I wonder if there is a blood test for these markers interleukin-8 and 17? I know there is a blood test for interleukin 2 and 6
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Jay Lackritz
Forum Leader
Username: Jay_ny
Post Number: 483
Registered: 01-2007
| | Posted on Wednesday, December 14, 2011 - 04:54 pm: |
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ajs,
I looked on your site. Wow! That's expensive! a 20 day supply for $22. And that's the largest that they sell. If you ordered one double box, which contains 40 doses, taken twice a day for 20 days, you would have to place another order almost the very day you receive it. 
I couldn't find anything twice as expensive as that, as you say,, but apparently, PharmaNAC comes as 900mg instead of 600mg, so I guess you are supposed to only take one a day in that dosage.
They charge $18.50 for 20, so if you take one 900 instead of two 600, then the PharmaNAC is cheaper, but they still only sell it in a 20 day supply.
Do you know why this is? Most supplements come in 30, 60, or 90 day supplies. I've never seen anything sold only in such small quantities. Does this suggest that you only use it for 3 weeks and then quit?
What do you think about 900mg once a day, vs. 600mg twice a day.
And yes, effervescent is rare and very hard to find, and ultra expensive, so I would imagine that it is not well accepted. The 600mg pills, on the other hand, only cost $22 for 300 pills, or 150 day supply for the same amount as a 20 day supply of the effervescent form. On the other hand, if the pills don't work, then they are also too expensive, and they are ripping off hundreds of customers.
Ref: http://www.bioadvantex.com/us/pharmanac.html
http://www.puritan.com/amino-acid-supplements-082/n-acetyl-cysteine-nac-600-mg-000214
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Jay Lackritz
Forum Leader
Username: Jay_ny
Post Number: 484
Registered: 01-2007
| | Posted on Wednesday, December 14, 2011 - 05:14 pm: |
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BTW,
The dosage of NAC is all over the map, depending on what disease you're taking it for.
For COPD, 600mg once a day is recommended. For chronic bronchitis, it is all over the place. Here's a quote from WebMD:
For preventing sudden worsening of chronic bronchitis: doses of 200 mg twice daily, 200 mg three times daily, 300 mg slow-release twice daily, and 600 mg controlled-release twice daily have been used.
For treating chronic obstructive pulmonary disease (COPD): 600 mg of N-acetyl cysteine once daily, in addition to standard care, has been used for up to 6 months.
I have seen wild swings in the recommended dosage. I never saw anywhere that 900mg is not nearly enough, and that you would need 1800mg in order to get your minimum of 1200mg as you said in your post.
PharmaNAC seems to be the main brand sold, and it only comes in the one size. On none of the sites, do they tell you to take 2 a day of this 900mg size. You mentioned the hundreds of studies. Do these say that 900mg a day won't cut it for the uses we would be taking it for?
When you say that Amazon.com is twice as expensive as the other site, is this also in the 600mg dose, or is the 900mg size twice as expensive as the 600mg dose?
Way confusing!
http://www.webmd.com/vitamins-supplements/ingredientmono-1018-N-ACETYL%20CYSTEINE.aspx?activeIngredientId=1018&activeIngredientName=N-ACETYL%20CYSTEINE
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ajs
Forum Leader
Username: Ajs
Post Number: 693
Registered: 03-2008
| | Posted on Wednesday, December 14, 2011 - 05:31 pm: |
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Jay- My take on the 900 vs. 600 is this; since the recommended dosage is 1200 a day, why would you even make it in 900? You would still need to take two to get the RDA. So, since they are selling it for $18.50 for 20, and we sell 40 for $22.00, it is almost half. My sister is not driving a Lexus because of this, believe me. But she is making a modest living, doesn't have to leave home, and it keeps getting better by the year from the word of mouth.
The tablets are not small, and when you wrap each one individually in foil, a box of 40 is a pretty good size. On the other hand, since it is more expensive than the pills, at least you don't have to make a big commitment before trying it. What usually happens, is people buy one box, and the results they get in 20 days are usually like the letter above, so they start buying more per order. For people like me, using it for something other than breaking up mucus, the results aren't as dramatic. But I just go back to my initial experience with it, where I went from having bronchitis twice a year, to having it once in 3 1/2 years. Those were real results to me.
I guess it seems a little expensive, but it's really a little over a dollar a day. OK, now I feel like Sally Struthers with the little sick children.....The other cool thing is to read all those testimonials at the site, and KNOW they are all 100% true.
from PharmaNAC's own website:
The recommended dose is two tablets per day. Avoid taking with any dairy products as the acidity of PharmaNAC is close to that of orange juice. PharmaNAC may be taken with or without food. It is recommended to take as an everyday immune booster and to enhance respiratory system function.
http://www.pharma-nac.com/faq/
Double-Lung transplant at Duke on 10/27/08
Pulmonary Fibrosis with traction bronchiectasis
http://healthierlungs.com
Live each day as if you were living forever, and live each moment as if it were your last.
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Jay Lackritz
Forum Leader
Username: Jay_ny
Post Number: 485
Registered: 01-2007
| | Posted on Wednesday, December 14, 2011 - 05:45 pm: |
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ajs,
Thanks for the quick response.
Who says the recommended dosage is 600mg twice a day, and for what disease? Most people I know who use NAC, use it for bronchitis for mucus, and WebMD, for example, says: doses of 200 mg twice daily, 200 mg three times daily, 300 mg slow-release twice daily, and 600 mg controlled-release twice daily have been used.
I have never seen any 'official' RDA for general use of NAC, and I still say that it's strange that there is only one brand of effervescent NAC sold and it's at the wrong dosage. When 'they' say 600mg, twice a day, and you can't buy 600mg of effervescent NAC, except from your sister, that is very odd.
BTW, I don't mean to suggest that your sister is gouging people. It's just odd that she sells it differently from any other available source in the world.
I don't know, maybe you should take one 900mg pill one day, and two the next.
Sorry to beat a dead horse, but the fact that almost everyone in the world uses the pills, and everyone who uses effervescent NAC, take 900mg, it's hard to believe that everyone is doing it wrong, except for the few customers of your wife.
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ajs
Forum Leader
Username: Ajs
Post Number: 694
Registered: 03-2008
| | Posted on Wednesday, December 14, 2011 - 06:01 pm: |
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Jay- See my addendum to my last post from PharmaNAC'a own website.
I'm just telling you most of the scientific studies I've read, 1200 was the dose used. I've been researching this stuff for 8 years Jay. You're dead wrong about 'all the people in the world use pills'. EVERY person in Germany who takes this product from Hexal, is recommended to take two a day. Holland, Italy, same thing, effervescent. You're not going to find studies about how much for which disease. Hell, that study from Belgium from 2004 is the only mention on the web about taking it to prevent BOS. It's my choice.
Most people buying it from my sister have COPD, or ALS, or respiratory diseases involving too much mucus. Take a look at the clinicaltrials.gov site, put in NAC. Do some research, as I don't have all your answers.
Double-Lung transplant at Duke on 10/27/08
Pulmonary Fibrosis with traction bronchiectasis
http://healthierlungs.com
Live each day as if you were living forever, and live each moment as if it were your last.
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ajs
Forum Leader
Username: Ajs
Post Number: 695
Registered: 03-2008
| | Posted on Thursday, December 15, 2011 - 08:22 pm: |
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Just saw this on Healthier Lungs, that I didn't even remember was there:
Letter from Steve Byer, co-founder of ALS Worldwide to a member:
Re thinning secretions (phlegm, mucus)--best resolution is effervescent acetylcysteine orally. It's NAC with effervescence and must be taken as a liquid (not capsule or pill). We recommend getting it from www.healthierlungs.com Person there is Savannah Taylor, her email is: savannah@healthierlungs.com They import it from Germany, it's not otherwise sold in US. Pretty inexpensive, can't remember exactly how much. It comes in sachets or tablets, dissolve in 1/2 cup water, swallow. Usually takes 2-4 days first time to work well, using 3-4 per day spread out. Then pt can cut down to 1 daily, possibly 2 if serious phlegm issue.
Works so well because of NAC action coupled with effervescence (looks a bit like an alka-seltzer). Have now used with hundred or more [patients] and everyone swears by it.
Hope this helps, best wishes, Steve
Stephen Byer
stephenbyer@alsworldwide.org
Double-Lung transplant at Duke on 10/27/08
Pulmonary Fibrosis with traction bronchiectasis
http://healthierlungs.com
Live each day as if you were living forever, and live each moment as if it were your last.
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