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Txnyny
Member
Username: Txnyny
Post Number: 1
Registered: 06-2014
| | Posted on Saturday, June 28, 2014 - 04:03 pm: | 
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Has anyone switched from Neoral to Prograf? What was your experience/what were the real side effects that you experienced on the drugs?
Thanks! |
Hostess Risé
Board Administrator
Username: Rise
Post Number: 18066
Registered: 05-2003
| | Posted on Saturday, June 28, 2014 - 07:49 pm: |
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YES! I switched almost 17 years ago and I really like Prograf.
We all have different experiences.
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Jay Lackritz
Forum Leader
Username: Jay_ny
Post Number: 595
Registered: 01-2007
| | Posted on Sunday, June 29, 2014 - 02:23 am: |
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Txnyny,
Prograf and neoral have very different side effect. For example, one makes your hair fall out and the other makes your hair grow when you don't want it to.
Prograf is the newer of the two drugs and many studies have shown lower rejection rates and higher survival rates with the newer drug. After Prograf made it into the transplant population, survival rates went up all over.
This is not to say that any one individual will see better or worse results with one over the other.
Most of the studies concern kidney transplants, since there are so many more of those than any other organ.
A well referenced wiki article states:
Tacrolimus (Prograf) has similar immunosuppressive properties to ciclosporin (Neoral), but is much more potent. Immunosuppression with tacrolimus was associated with a significantly lower rate of acute rejection compared with ciclosporin-based immunosuppression (30.7% vs 46.4%) in one study. Clinical outcome is better with tacrolimus than with ciclosporin during the first year of liver transplantation. Long term outcome has not been improved to the same extent. Tacrolimus is normally prescribed as part of a post-transplant cocktail including steroids, mycophenolate and IL-2 receptor inhibitors. Dosages are titrated to target blood levels. Typical starting doses for once daily tacrolimus are 0.15-0.20 mg/kg body weight.
http://www.medscape.com/viewarticle/474429
I'm also sure that you can find studies that state the opposite, but again, it depends on the individuals and other meds and which organ they received.
Personally, after my double lung 7 years ago, I was put on prograf, and I'm still on it.
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