| Author |
Message |
ed
Forum Leader
Username: Ed2001
Post Number: 261
Registered: 03-2010
| | Posted on Saturday, October 08, 2011 - 08:55 am: | 
|
Here's an interesting article that may explain why taking CNIs, ie. prograf or cyclosporine, increases or causes high BP or potassium problems in some of us. Take note however, that some people still have high BP or potassium levels post transplant which isn't caused by the CNIs, so this pretty much involves making sure first that it is really the CNIs causing the problem.
http://www.sciencedaily.com/releases/2011/10/111007103310.htm
From what it says, it really depends on whether you have a particular protein. If you do, you become susceptible to the CNIs effects. The good news is that a particular type of BP drug solves this by suppressing the protein, which is probably the reason I've seen nephs keep trying numerous combinations of BP drugs for those who have stubborn BP, until they get the one/s that work.
Hope this helps someone here, as I know how it feels to have issues where there is a 'weird' and stubborn issue that no one seems to know how to solve, and ends up being remedied by a simple solution but only after you've gone though a lot of troubles or anxiety with it.
Kidney Transplant
April 2001 |
|
Alaskagal
Member
Username: Cheathers
Post Number: 27
Registered: 06-2011
| | Posted on Saturday, October 08, 2011 - 10:43 am: |
|
Thanks so much Ed! There really is a lot of information in that article, and I also see some other articles on the side bar. I have bookmarked that sight and will keep watching it. As a very new transplant patient, I have a lot to learn.... you all are very helpful here. Blessings!
Heather |
gra8ful2
Member
Username: Kesh
Post Number: 13
Registered: 07-2007
| | Posted on Monday, December 19, 2011 - 10:03 pm: |
|
This is awesome. I just figured out this week that it is the medication causing my hypertension. This is the very reason why I came to the Buddies site today! Your information arms me to discuss this issue with the doctor yet again, and to present a viable solution this time. Thanks so much! You answered a prayer! |
cruizin
Member
Username: Cruizin
Post Number: 223
Registered: 09-2010
| | Posted on Tuesday, December 20, 2011 - 12:45 pm: |
|
Thanks Ed, this is useful info for me, as I am one of those going through BP meds until something works.
Received kidney Mar 16, 2011, from my brother! 3/6 match
St. Joe's, Hamilton, ON
Peritoneal dialysis Nov '08 - Mar '11
Dx 1995 - believed to be chronic glomerulonephritis
Started CAPD Oct 2008 |
|
cruizin
Member
Username: Cruizin
Post Number: 224
Registered: 09-2010
| | Posted on Tuesday, December 20, 2011 - 01:41 pm: |
|
Hmm so I just looked at the reviews of the drug mentioned in this article (hydrochlorothiazide) and it's a erection-killer for guys.
It seems almost all these BP drugs have this effect, at least the last two I've been on.
I sure hope I can find one that lowers BP and leaves my libido alone!
Received kidney Mar 16, 2011, from my brother! 3/6 match
St. Joe's, Hamilton, ON
Peritoneal dialysis Nov '08 - Mar '11
Dx 1995 - believed to be chronic glomerulonephritis
Started CAPD Oct 2008 |
|
John83
Member
Username: John83
Post Number: 178
Registered: 10-2007
| | Posted on Friday, December 23, 2011 - 08:13 pm: |
|
Have you tried amlodipine? |
cruizin
Member
Username: Cruizin
Post Number: 226
Registered: 09-2010
| | Posted on Tuesday, January 03, 2012 - 02:32 pm: |
|
Sorry for the late reply. Yes I tried amlodipine, with significant side effects. You can see my post here: http://www.transplantbuddies.org/tbx/messages/7/536384.html?1324597425
Received kidney Mar 16, 2011, from my brother! 3/6 match
St. Joe's, Hamilton, ON
Peritoneal dialysis Nov '08 - Mar '11
Dx 1995 - believed to be chronic glomerulonephritis
Started CAPD Oct 2008 |
|
bill s
Member
Username: Bill_s
Post Number: 79
Registered: 08-2011
| | Posted on Tuesday, January 03, 2012 - 05:04 pm: |
|
I have been taking a variety of BP meds for some time. After getting my kidney TX they put me on 10 mg amlodipine and 50 mg metoprolol. I measure my BP several times a day to tune my BP meds for the optimum BP (120/70). I changed my meds over time so that now I am taking 15mg amlodipine, 0.4mg clonidine and 12.5mg metoprolol. The only side effects I get are from the amlodipine which causes edema in my lower legs and feet. If I walk 4 miles the muscle movement and more rapid heartbeat help to pump the extra liguid in my feet/ankles back up into my body (or sit with your feet raised). The amlodipine is recommended to lower the systolic BP while the metoprolol and clonidine lower the diastolic BP. Even so, my BP still wanders around quite a bit such that I think my diet must be having some effect. Metoprolol also decreases the heart rate - mine has been as low as 49 - thus the reason for trying to tune the meds. I was on lisinopril at one time but the docs stopped it because it made the creatinine level go up slightly. If I don't have good success with the meds i'm now using I may try lisinopril again. |
