Post Number: 1
|Posted on Friday, March 09, 2012 - 02:03 pm: ||
Has anyone with a kidney pancreas transplant been taken off Prograf and put on something else? My partner's blood sugars are ok for a while and then high and then ok and it seems to correlate with the Prograf levels but I'm not sure it's that. I've heard that Prograf is the best immunosupress drug but I've also heard there are alternatives. Any insight would be greatly appreciated.
Post Number: 454
|Posted on Friday, March 09, 2012 - 02:30 pm: ||
I had a kidney tx in 2002 and was on prograf and rapamune. I had to change the prograf for myfotic because of toxicity to the kidney. I had a pancreas transplant in 2008 and was put on prograf again (with the myfortic) because they felt that the pancreas would do better with it. Unfortunately, I had kidney problems again so they put me back to my old regime of rapa and myfortic. I have been on this combo for roughly 3 years now and I am doing fine (knock on wood). Btw, myfortic is like cellcept only formulated to be easier on the stomach.
|Dx with T1 in 1966 |
Kidney tx in Minneapolis 2002
Pancreas tx in 2008
Post Number: 15
|Posted on Friday, March 09, 2012 - 03:53 pm: ||
I've been on Profraf and cellcept since my transplant last summer. I haven't noticed any variation in blood sugar based on my Prograf levels but I have noticed a wide swing based on what I eat before I go for my blood work. I'm on two week blood draws and every other blood draw I fast before because of the cholesterol and triglyceride tests. When I fast my glucose is always 15 - 30 points lower than when I eat breakfast before the blood draw. Have you checked the correlation between your eating and glucose?
|Kidney Tx - Aug 4, 2011 |
VA Pittsburgh Health Care Center
Follow UPMC non-steroidal protocol
Live donor was my radio operator in Vietnam
Post Number: 300
|Posted on Saturday, March 10, 2012 - 04:51 am: ||
There are a number of alternatives to prograf. Cyclosporine, which is prograf's predecessor works in a similar way to how prograf works but doesn't affect blood sugars much. Then as Cora mentioned, there is rapamune and also everolimus, both of which belong to the mTOR class, and have been used with cellcept or myfortic to replace prograf.
The other thing could be prednisone, unless your center uses a non-steroid protocol.
The concern here is to be able to make sure that prograf is the cause before your doctor decides to switch.
|Kidney Transplant |
Post Number: 251
|Posted on Monday, March 12, 2012 - 09:23 am: ||
Some people are being switched to a new drug called Belatacept. It's a once-monthly injection. Emory in Georgia in particular does a lot with that drug.
|Received kidney Mar 16, 2011, from my brother! 3/6 match |
St. Joe's, Hamilton, ON
Peritoneal dialysis Nov '08 - Mar '11
Dx 1995 - believed to be chronic glomerulonephritis
Started CAPD Oct 2008